Title
What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping
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Start date: 01/10/2017
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End date: 01/04/2021
2020-01-09
Title
What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping
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Start date: 01/10/2017
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End date: 01/04/2021
Aim
Identify metabolites that sit on the causal pathway from increased adiposity to disease
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Objectives
Proportion of overweight individuals
Proportion of obese individuals
Can we build a flowchart of decisions to achieve this?
Intro/overview
MELODI analysis: 975,402 articles; 10,828 enriched terms, filtering left 77 terms, 8 categories plus ‘Other’
| Cancer | Cardiovascular | Immune | Kidney | Liver | Neuro_behav | Pregnancy | Respiratory | Other |
|---|---|---|---|---|---|---|---|---|
| Primary carcinoma of the liver cells | Heart failure | Pancreatitis | End stage renal failure | Liver diseases | Depressive disorder | Pre-Eclampsia | Tuberculosis | Metabolic syndrome |
| Malignant neoplasm of stomach | Anemia | Inflammatory disorder | Kidney Failure, Chronic | Non-alcoholic fatty liver | Dementia | Pregnancy | Sleep Apnea, Obstructive | Cessation of life |
| Malignant neoplasm of prostate | Dyslipidemias | Immunocompromised Host | Glomerular Filtration Rate | Liver and Intrahepatic Biliary Tract Carcinoma | Hypertension induced by pregnancy | Pneumonia | Malnutrition | |
| Malignant neoplasm of lung | Cerebrovascular accident | Bacteremia | Kidney Diseases | Chronic liver disease | Chronic Obstructive Airway Disease | Diabetic | ||
| Common Neoplasm | Cardiovascular Diseases | Septicemia | Kidney Failure | Respiration Disorders | Multiple Organ Failure | |||
| Liver neoplasms | Atherosclerosis | Lupus Erythematosus, Systemic | Renal function | Respiratory Distress Syndrome, Adult | Fibrosis | |||
| Malignant disease | Myocardial Infarction | Sepsis Syndrome | Respiratory Tract Infections | Deglutition Disorders | ||||
| Carcinoma of the Large Intestine | Ischemic stroke | Respiratory Failure | Vitamin D Deficiency | |||||
| Pancreatic carcinoma | Acute coronary syndrome | Acute respiratory failure | ||||||
| Atrial Fibrillation | ||||||||
| Coronary heart disease | ||||||||
| Systemic arterial pressure | ||||||||
| Thrombosis | ||||||||
| Cerebrovascular Disorders | ||||||||
| Acute myocardial infarction | ||||||||
| Sinus rhythm | ||||||||
| Cardiomyopathies | ||||||||
| Myocardial Ischemia | ||||||||
| Peripheral Vascular Diseases | ||||||||
| Vascular calcification | ||||||||
| Heart Arrest | ||||||||
| Myocardial rupture | ||||||||
| Shock, Cardiogenic | ||||||||
| Hemorrhage | ||||||||
| Ischemia | ||||||||
| Congestive heart failure | ||||||||
| Ventricular Dysfunction, Left | ||||||||
| Mitral Valve Insufficiency | ||||||||
| Hyperglycaemia |
Systematic review
All MR studies using a measure of increased adiposity as the exposure; ~150 articles included
Instrumentation
Observational analysis
Waiting on Biobank data…
MR step 1
MR Viz
library(EpiCircos)
circos_plot(track_number = 3,
track1_data = EpiCircos::EpiCircos_data,
track2_data = EpiCircos::EpiCircos_data,
track3_data = EpiCircos::EpiCircos_data,
track1_type = "points", track2_type = "lines", track3_type = "bar",
label_column = 1, section_column = 2,
estimate_column = 4, pvalue_column = 5,
pvalue_adjustment = 1,
lower_ci = 7, upper_ci = 8,
lines_column = 10, lines_type = "o",
bar_column = 9,
legend = TRUE,
track1_label = "Track 1",
track2_label = "Track 2",
track3_label = "Track 3",
pvalue_label = "<= 0.05",
circle_size = 25)
Clustering metabolites
not started
Writing (0%)
Priors
Rules for instrumenting clusters
MR step 2
Discussion/limitations/conclusion